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Selected Publications

Cytokines and cytokine receptors

  • Schnyder B, Lugli S., Feng N., Etter H., Lutz R.A., Ryffel B., Sugamura K., Wunderli-Allenspach H., Moser R. (1996) IL-4- and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular cell adhesion molecule-1 induction in the absence of the common g chain (gc). Blood: 87: 4286-4295 [15.0 KB]
  • Schnyder, B., S.M. Lugli, S. Schnyder-Candrian, V.M. Eng, R.Moser, J. Banchereau, B. Ryffel, B.D. Car. (1996) Biochemical and morphological characterization of vascular and lymphocytic IL-4 receptors. Am. J. Pathol. 149: 1369-1379
  • Lugli S.M., Feng N., Heim M., Adam M., Schnyder B., Etter H., Yamage M. , Eugster H.P. , Lutz R.A., Zurawski G., Moser R. (1997) TNF-a enhances the expression of the IL-4 receptor a-chain of endothelial cells increasing IL-4 or IL-13-induced STAT6 activation. J. Biol. Chem. 272: 5487-5494 [385 KB]
  • Gauchat J. F., Schlagenhauf E. , Feng N., Moser R., Yamage M., Jeannin P., Alouani S., Elson G., Notarangelo L. D., Wells T., Eugster H.P., Bonnefoy J.Y. (1997) A novel 4kb interleukin-13 receptor a mRNA expressed in human B,T, and endothelial cells encoding for an alternate type II interleukin-4/interleukin-13 receptor. Eur. J. Immunol. 27: 971-978
  • Feng, N., Lugli, S.M., Gauchat, J.F.M., Graber, P., Schlagenhauf, E., Schnarr, B., Wiederkehr-Adam, M., Duschl, A., Heim M.H., Lutz R.A., Moser, R. 1998. The Interleukin (IL)-4/IL-13 Receptor of Human Synovial Fibroblasts: Overexpression of the non-signalling IL-13 Receptor a2. Lab. Invest. 78: 591 - 602.
  • Lacki, J.K., Moser, R., Korczowska, I, Mackiewicz, S., Muller, W. 2000 TNF-alpha gene polymorphism does not affect the clinical and radiological outcome of rheumatoid arthritis. Rheumatol. Int. 19:4 137-140.
  • D. Koller, C. Ruedl, M. Loetscher, J. Vlach, S. Oehen, K. Oertle, M. Schirinzi, E. Deneuve, R. Moser, M. Kopf, J. E. Bailey, W. Renner and M. F. Bachmann. 2001 A high-throughput alphavirus-based expression cloning system for mammalian cells. Nature Biotechnology 19:851-855 [PDF]

Leukocytes and vascular biology

  • Fehr J., Moser R., Leppert D., Groscurth P. (1985) Antiadhesive properties of biological surfaces are protective against stimulated granulocytes.
    J. Clin. Invest. 76: 535-542.
  • Moser R., Groscurth, P., Fehr J. (1986) Interleukin-1 stimulates human vascular endothelial cells to promote transendothelial neutrophil migration.
    Clin. Res. 34: 502A.
  • Kadletz M. Moser R., Preiss P. (1987) In vitro lining of fibronectin coated PTFE grafts with cryopreserved saphenous vein endothelial cells.
    J. Thorac. Cardiov. Sur. 35 :143-147.
  • Moser R., Schleiffenbaum B., Groscurth P., Fehr J. (1989) Interleukin-1 and tumor necrosis factor stimulate human vascular endothelial cells to promote transendothelial neutrophil passage. J. Clin. Invest. 83: 444-455.
  • Schleiffenbaum, B., Moser R., Patarroyo M., Fehr J. (1989) The cell surface glycoprotein Mac-1 (CD11b/CD18) mediates neutrophil adhesion and modulates degranulation independently of its quantitative cell surface expression. J. Immunol. 142: 3537-3545.
  • Moser R., Groscurth P., Fehr J. (1990) Promotion of transendothelial neutrophil passage by human thrombin. J. Cell Sci. 96: 737-744.
  • Schleiffenbaum B., Moser R., Fehr J. (1990) A defect in chemotaxis from IL-2 (letter). New Engl. J. Med. 323: 682-683.
  • Moser R., Fehr J., Olgiati L., Bruijnzeel P. L. B. (1992) Migration of primed human eosinophils across cytokine-activated endothelial cell monolayers.
    Blood 79: 2937-2945.
  • Moser R., Fehr J., Bruijnzeel P. L. B. (1992) Interleukin-4 controls the selective endothelium-driven extravasation of eosinophils from allergic individuals.
    J. Immunol. 149: 1432-1438.
  • Moser R., Olgiati L., Patarroyo M., Fehr J. (1993) Chemotaxins Inhibit Neutrophil Fc-mediated Cytotoxicity and Endothelium-dependent Adherence and Transmigration induced by Cytokines: Correlation to the Expression of L-Selectin. Eur. J. Immunol. 23: 1481-1487.
  • Moser R., Groscurth P., Carballido J.M., Bruijnzeel P.L.B., Blaser K., Heusser C.H., Fehr J. (1993) Interleukin-4 induces tissue eosinophilia in mice: Correlation with its in vitro capacity to stimulate the endothelial cell-dependent selective transmigration of human eosinophils. J . Lab. Clin. Med. 122: 567-575.
  • Weisser B., Locher R., deGraaf J., Moser R., Sachinidis A., Vetter W. (1993) Low density lipoprotein subfractions increase thromboxane formation in endothelial cells. Biochem. Biophys. Res. comm. 192: 1245-1250.
  • Vollenweider I., Moser R., Groscurth P. (1994) Development of four donor-specific phenotypes in human long-term lymphokine-activated killer cell cultures. Cancer Immunol. Immunother. 39: 305-312.
  • Santamaria L.F., Moser R., Perez-Soler M.T., Picker L.J., Blaser K., Hauser C. (1994). The migration of skin-homing T cells across cytokine-activated human endothelial cell layers involves interaction of cutaneous lymphocyte antigen (CLA), the very-late- antigen-4 (VLA-4) and the lymphocyte function-associated antigen. J. Immunol. 154: 1543-1550.
  • Moser R., Etter H., Olgiati L., Fehr J. (1995) Neutrophil activation in response to immune complex-bearing endothelial cells depends on the functional cooperation of FcgRII (CD32) and FcgRIII (CD16). J. Lab. Clin. Med.:126: 588-596.
  • Santamaria L.F., Moser B., Perez-Soler M.T., Moser R., Loetscher P., Villiger B., Blaser K., Hauser C. (1996) The interleukin-8 receptor B and CXC chemokines can mediate transendothelial migration of human skin homing T cells. Eur. J. Immunol. 26: 2056-2061.
  • Fröhlich, D., Spertini, O., Moser R. 1998.The Fcg receptor-mediated respiratory burst of rolling neutrophils to cytokine-activated immune complex-bearing endothelial cells depends on L-selectin but not on E-selectin. Blood 91: 2558 -2564 [153 KB]
  • Etter, H., Althaus, R., Eugster, H.P., Santamaria-Babi, L., Weber, L., Moser, R. 1998. IL-4 and IL-13 control rolling adhesion of leukocytes to IL-1 or TNF-a-activated endothelial cells by limiting the interval of E-selectin expression. Cytokine 10: 395-403
  • Silvia Schnyder-Candrian, Lubor Borsig, René Moser, Eric G. Berger. 2000. Localization of a1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cells. Proc. Natl. Acad. Sci. USA 97: 8369 - 8374 [787 KB]
  • Silvia Schnyder-Candrian, Isabelle Maillet, Marc Le Bert, Lea Brault, Muazzam Jacobs, Bernhard Ryffel Bruno Schnyder, and René Moser. 2012. Neutrophil Inhibitory Factor Selectively Inhibits the Endothelium-Driven Transmigration of Eosinophils In Vitro and Airway Eosinophilia in OVA-Induced Allergic Lung Inflammation Journal of Allergy 2012

Immune cell infiltration in 3D biomimetic microtissues

  • Herter S., Morra L., Schlenker R., · Sulcova J.,· Fahrni L, Waldhauer I., Lehmann S., · Reisländer T., Agarkova I., Kelm J. M., Klein C., · Umana P., · Bacac M., (2017) A novel three‑dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents. Cancer Immunol Immunother (2017) 66:129–140.

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